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Our well-planned sequence of studies in PoV generally tests the most significant value drivers as early as possible, so that decisions are made with minimum expenditure


How Proof of Value Differs from Proof of Concept

A Proof of Concept (PoC) is a short and/or incomplete realization (or synopsis) of a certain method or idea to demonstrate its feasibility. The proof of concept is usually considered a milestone on the way to a fully functioning prototype.

In the clinical development context, PoC is usually narrowly defined as efficacy in one indication. Bound by these traditional constraints, optimal PoC cannot be defined. This is biased toward failure, and has led to the blockbuster mentality that currently governs the biopharmaceutical industry.

Proof of Value™ (PoV) more broadly addresses all the requirements for enhanced value that lead to therapeutic success. With a tolerance for more than one right answer, therapeutic value can be redefined as new data and knowledge emerges about the compound. Broader therapeutic success – such as extended indications or alternate uses – begets broader commercial success while lowering the risks and costs of achieving it.

Figure 2: Proof of Value vs Proof of Concept